A NEW FRONTIER
Tune Therapeutics is pioneering the next generation of genetic therapies.
Historically, genetic medicine has focused almost exclusively on changes within protein-coding genes. Yet only a fraction of the genetics associated with disease involves changes of this type.
The vast majority of human disease is the result of changes in gene expression, driven by epigenomic regulators that determine cell state and fate.
By exploring this new landscape of epigenomic control, we are discovering novel targets that are invisible or inaccessible to other approaches.
Genetic tuning enables us to control expression levels across multiple genes simultaneously, by affecting the packing and accessibility of cellular DNA.
Unlike genome editing, our proprietary TEMPO platform dials the volume of gene expression up or down towards healthy levels, without breaking or permanently rewriting DNA – and it can do this in multiple genes at once (multiplexing). This allows us to change cell fate and function at will, unlocking the ability to reverse pathways of cancer, genetic disease and aging.
Our approach effectively expands the potential reach of genetic medicine – from targeting a limited range of rare conditions, to overcoming thousands of complex and chronic diseases that currently have no curative treatment.
Tune is driven by leaders with deep expertise in the fields of gene and cell therapy, genome editing, and epigenetics. In breaking free from the limitations of traditional genetic medicine, we are developing solutions for even the most challenging and intractable diseases – and building the capacity to transform human health and medicine.
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